Anemia in Lymphoproliferative Disorders.

The etiologies of anemia in patients with lymphoproliferative disorder (LPD) are diverse. Causes such as acute blood loss or deficiencies in iron or vitamins (folate/B12) are considered in the initial evaluation. In many instances, the anemia can be attributed to marrow infiltration by the LPD. Treatment with chemotherapy can suppress erythropoiesis. Other causes that occur more often with LPD are autoimmune phenomena such as autoimmune hemolytic anemia (AIHA) or pure red cell aplasia (PRCA). Finally, after excluding these conditions, anemia of chronic disease (ACD) is considered as the basis for the anemia.